Long non-coding RNA - Wikipedia
WebLong non-coding RNAs (long ncRNAs, lncRNA) are a type of RNA, generally defined as transcripts more than 200 nucleotides that are not translated into protein. This arbitrary limit distinguishes long ncRNAs from small non-coding RNAs , such as microRNAs (miRNAs), small interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar ...
Long non-coding RNAs: definitions, functions, challenges and
WebJan 3, 2023 · The term ‘lncRNAs’ encompasses RNA polymerase I (Pol I), Pol II and Pol III transcribed RNAs, and RNAs from processed introns. The various functions of lncRNAs and their many isoforms and...
Gene regulation by long non-coding RNAs and its biological ... - Nature
WebDec 22, 2020 · Depending on their localization and their specific interactions with DNA, RNA and proteins, lncRNAs can modulate chromatin function, regulate the assembly and function of membraneless nuclear...
Long non-coding RNAs: From disease code to drug role - PMC
WebOct 10, 2020 · This paper has focused on the emerging research into lncRNAs as pharmacological targets and has reviewed the transition of lncRNAs from the role of disease coding to acting as drug candidates, including the current status and progress in preclinical research.
Cellular functions of long noncoding RNAs | Nature Cell Biology
WebMay 2, 2019 · Abstract. A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential, are transcribed from the mammalian genome. They are emerging as important regulators in gene ...
The how and why of lncRNA function: An innate immune …
WebSep 2, 2019 · Long noncoding RNAs (lncRNAs) represent the largest group of non-coding RNAs produced from the genome. LncRNAs are defined as transcripts >200 nucleotides in length, lacking protein-coding potential. In the most recent GENCODE V30 release, there are 16,193 annotated lncRNAs in the human genome [ 4 ].
Long non-coding RNAs: Biogenesis, functions, and clinical …
WebDec 12, 2021 · Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs with a length of more than 200 nt. They play crucial roles in a wide spectrum of physiological and pathological processes by regulating the expression of genes involved in proliferation, differentiation, apoptosis, cell cycle, invasion, metastasis, DNA damage, and …
From structure to function: Route to understanding lncRNA …
WebNov 9, 2020 · Per definition, lncRNAs are over 200 nucleotides in length, lack a protein-coding potential, can be spliced, capped, and/or polyadenylated and are localized either in the nucleus or the cytoplasm of the cell. [ 1, 3] LncRNAs are involved in a multitude of biological processes.
LNCcation: lncRNA localization and function - PubMed
WebFeb 1, 2021 · In this review, we summarize current knowledge of lncRNA subcellular localization, factors controlling their localization, emerging themes, including the role of lncRNA isoforms and the involvement of lncRNAs in phase separation bodies, and the implications of lncRNA localization on their function and on cellular behavior.
History, Discovery, and Classification of lncRNAs - PubMed
WebAbstract. The RNA World Hypothesis suggests that prebiotic life revolved around RNA instead of DNA and proteins. Although modern cells have changed significantly in 4 billion years, RNA has maintained its central role in cell biology. Since the discovery of DNA at the end of the nineteenth century, RNA has been extensively studied.
Transcription regulation by long non-coding RNAs: mechanisms …
WebJan 19, 2024 · Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the control of gene...
Long Non-Coding RNAs: The Regulatory Mechanisms, Research Strategies ...
WebDec 18, 2020 · Abstract. The development and application of whole genome sequencing technology has greatly broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs are more than 200 nucleotides in length …
Long Noncoding RNA - an overview | ScienceDirect Topics
WebLong noncoding RNAs (lncRNAs) represent a class of transcribed RNA molecules that are longer than 200 nucleotides and yet do not encode proteins.
What's the Difference Between lncRNA and lincRNA? - G …
WebWhat are lncRNAs? There was a time when researchers considered lncRNAs as nothing more than “junk DNA” since these RNA sequence transcripts do not translate into a protein product. However, recent studies suggest otherwise. Research shows that lncRNAs may function by binding to proteins and DNA or RNA in a sequence-specific manner.
On the classification of long non-coding RNAs - PubMed
WebLong non-coding RNAs (lncRNAs) have been found to perform various functions in a wide variety of important biological processes. To make easier interpretation of lncRNA functionality and conduct deep mining on these transcribed sequences, it is convenient to classify lncRNAs into different groups.
Mechanisms of lncRNA biogenesis as revealed by nascent
WebJan 25, 2022 · In this Review, we provide insight into the regulation of lncRNA transcription and processing gleaned from the application of recently devised nascent transcriptomics technology.
Integration of transcription regulation and functional genomic …
WebFeb 28, 2024 · Abstract. Background. Long non-coding RNAs (lncRNAs) are pivotal players in cellular processes, and their unique cell-type specific expression patterns render them attractive biomarkers and therapeutic targets. Yet, the functional roles of most lncRNAs remain enigmatic.
LNCcation: lncRNA localization and function - PMC - National …
WebFeb 1, 2021 · Because lncRNAs are defined as RNA transcripts >200 nucleotides that do not encode protein, they are themselves the functional units, making their subcellular localization critical to their function.
What are lncRNAs and lincRNAs - Bio-Syn
WebJul 12, 2013 · Long noncoding RNAs, or lncRNAs, are recently discovered RNA molecules. lncRNAs represent a class of long transcribed RNA molecules that are longer than 200 nucleotides. lncRNA transcripts do not code for proteins.
Long Noncoding RNAs: Past, Present, and Future - PMC
WebNov 1, 2012 · Long noncoding RNAs (lncRNAs) have gained widespread attention in recent years as a potentially new and crucial layer of biological regulation. lncRNAs of all kinds have been implicated in a range of developmental processes and diseases, but knowledge of the mechanisms by which they act is still surprisingly limited, and claims …
Long Non-Coding RNAs - RNA / BOC Sciences
WeblncRNA: lncRNA is an abbreviation for long non-coding RNA molecule between 200 and 100,000 nt in length. Most lncRNA have significant spatiotemporal expression specificity during tissue differentiation and development. The sequence conservation of lncRNA is low, and only about 12% of lncRNA can be found in organisms other than humans.
Targeting and engineering long non-coding RNAs for cancer …
WebFeb 29, 2024 · Amongst the most promising targets are long non-coding RNAs (lncRNAs), which regulate oncogenic molecular networks in a cell type-restricted manner. lncRNAs are distinct from protein-coding genes...
Mechanisms and Functions of Long Non-Coding RNAs at …
WebNov 8, 2019 · Long non-coding (lnc) RNAs are non-coding RNAs longer than 200 nt. lncRNAs primarily interact with mRNA, DNA, protein, and miRNA and consequently regulate gene expression at the epigenetic, transcriptional, post-transcriptional, translational, and post-translational levels in a variety of ways.
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